BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

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BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). To this end, we us...

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Auteurs principaux:	Marta Gómez-Almería, Sonia Burgaz, Carlos Costas-Insua, Carmen Rodríguez-Cueto, Irene Santos-García, Ignacio Rodríguez-Crespo, Concepción García, Manuel Guzmán, Eva de Lago, Javier Fernández-Ruiz
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	cannabinoids CB<sub>1</sub> receptors BiP interactor protein BiP<sup>+/−</sup> mice mSOD1 mice amyotrophic lateral sclerosis Biology (General) QH301-705.5 Chemistry QD1-999
Accès en ligne:	https://doaj.org/article/0596c9acd46f48c0a93625dc3145c5b7
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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