Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease

Abstract Increasing evidence supports the role of brain and systemic inflammation in the etiology of Parkinson disease (PD). We used gene expression profiling to examine the activation state of peripheral blood monocytes in 18 patients with early, untreated PD and 16 healthy control (HC) subjects. M...

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Autores principales:	Samantha M. Carlisle, Hongwei Qin, R. Curtis Hendrickson, Jordana E. Muwanguzi, Elliot J. Lefkowitz, Richard E. Kennedy, Zhaoqi Yan, Talene A. Yacoubian, Etty N. Benveniste, Andrew B. West, Ashley S. Harms, David G. Standaert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/05be2d31917548968fb8f99ff6f9f339
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spelling	oai:doaj.org-article:05be2d31917548968fb8f99ff6f9f3392021-12-02T15:51:20ZSex-based differences in the activation of peripheral blood monocytes in early Parkinson disease10.1038/s41531-021-00180-z2373-8057https://doaj.org/article/05be2d31917548968fb8f99ff6f9f3392021-04-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00180-zhttps://doaj.org/toc/2373-8057Abstract Increasing evidence supports the role of brain and systemic inflammation in the etiology of Parkinson disease (PD). We used gene expression profiling to examine the activation state of peripheral blood monocytes in 18 patients with early, untreated PD and 16 healthy control (HC) subjects. Monocytes were isolated by negative selection, and gene expression studied by RNA-seq and gene set enrichment analysis. A computational model that incorporated case/control status, sex, and the interaction between case/control status and sex was utilized. We found that there was a striking effect of sex on monocyte gene expression. There was inflammatory activation of monocytes in females with PD, with enrichment of gene sets associated with interferon gamma stimulation. In males, the activation patterns were more heterogeneous. These data point to the importance of systemic monocyte activation in PD, and the importance of studies which examine the differential effects of sex on pathophysiology of the disease.Samantha M. CarlisleHongwei QinR. Curtis HendricksonJordana E. MuwanguziElliot J. LefkowitzRichard E. KennedyZhaoqi YanTalene A. YacoubianEtty N. BenvenisteAndrew B. WestAshley S. HarmsDavid G. StandaertNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Samantha M. Carlisle Hongwei Qin R. Curtis Hendrickson Jordana E. Muwanguzi Elliot J. Lefkowitz Richard E. Kennedy Zhaoqi Yan Talene A. Yacoubian Etty N. Benveniste Andrew B. West Ashley S. Harms David G. Standaert Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
description	Abstract Increasing evidence supports the role of brain and systemic inflammation in the etiology of Parkinson disease (PD). We used gene expression profiling to examine the activation state of peripheral blood monocytes in 18 patients with early, untreated PD and 16 healthy control (HC) subjects. Monocytes were isolated by negative selection, and gene expression studied by RNA-seq and gene set enrichment analysis. A computational model that incorporated case/control status, sex, and the interaction between case/control status and sex was utilized. We found that there was a striking effect of sex on monocyte gene expression. There was inflammatory activation of monocytes in females with PD, with enrichment of gene sets associated with interferon gamma stimulation. In males, the activation patterns were more heterogeneous. These data point to the importance of systemic monocyte activation in PD, and the importance of studies which examine the differential effects of sex on pathophysiology of the disease.
format	article
author	Samantha M. Carlisle Hongwei Qin R. Curtis Hendrickson Jordana E. Muwanguzi Elliot J. Lefkowitz Richard E. Kennedy Zhaoqi Yan Talene A. Yacoubian Etty N. Benveniste Andrew B. West Ashley S. Harms David G. Standaert
author_facet	Samantha M. Carlisle Hongwei Qin R. Curtis Hendrickson Jordana E. Muwanguzi Elliot J. Lefkowitz Richard E. Kennedy Zhaoqi Yan Talene A. Yacoubian Etty N. Benveniste Andrew B. West Ashley S. Harms David G. Standaert
author_sort	Samantha M. Carlisle
title	Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
title_short	Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
title_full	Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
title_fullStr	Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
title_full_unstemmed	Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
title_sort	sex-based differences in the activation of peripheral blood monocytes in early parkinson disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05be2d31917548968fb8f99ff6f9f339
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Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease

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