Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes.
Complex diseases are often highly heritable. However, for many complex traits only a small proportion of the heritability can be explained by observed genetic variants in traditional genome-wide association (GWA) studies. Moreover, for some of those traits few significant SNPs have been identified....
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| Auteurs principaux: | , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2011
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| Accès en ligne: | https://doaj.org/article/05d4391e243f4e0299ae9ca865085982 |
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