NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of <named-content content-type="genus-species">Toxoplasma gondii</named-content> in Naive Macrophages

ABSTRACT Phagocytic cells are the first line of innate defense against intracellular pathogens, and yet Toxoplasma gondii is renowned for its ability to survive in macrophages, although this paradigm is based on virulent type I parasites. Surprisingly, we find that avirulent type III parasites are p...

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Bibliographic Details
Main Authors: Sumit K. Matta, Kelley Patten, Quiling Wang, Bae-Hoon Kim, John D. MacMicking, L. David Sibley
Format: article
Language:EN
Published: American Society for Microbiology 2018
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Online Access:https://doaj.org/article/05d7459d3eb746b58b99737082200792
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