NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of <named-content content-type="genus-species">Toxoplasma gondii</named-content> in Naive Macrophages

NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of <named-content content-type="genus-species">Toxoplasma gondii</named-content> in Naive Macrophages

ABSTRACT Phagocytic cells are the first line of innate defense against intracellular pathogens, and yet Toxoplasma gondii is renowned for its ability to survive in macrophages, although this paradigm is based on virulent type I parasites. Surprisingly, we find that avirulent type III parasites are p...

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Autores principales: Sumit K. Matta, Kelley Patten, Quiling Wang, Bae-Hoon Kim, John D. MacMicking, L. David Sibley
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
autophagy
chronic granulomatous disease
innate immunity
interferons
intracellular parasites
membrane damage
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/05d7459d3eb746b58b99737082200792
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