Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation

ADP-ribose erasing enzymes are increasingly recognized as critical regulators of protein ADP-ribosylation dynamics in living systems. Here, the authors review recent advances in the discovery and characterization of ADP-ribose erasers and discuss their role within the cellular ADP-ribosylation machi...

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Auteurs principaux: Julia O’Sullivan, Maria Tedim Ferreira, Jean-Philippe Gagné, Ajit K. Sharma, Michael J. Hendzel, Jean-Yves Masson, Guy G. Poirier
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/05d8f39e0141460487e8fe00b0a3d6e4
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Résumé:ADP-ribose erasing enzymes are increasingly recognized as critical regulators of protein ADP-ribosylation dynamics in living systems. Here, the authors review recent advances in the discovery and characterization of ADP-ribose erasers and discuss their role within the cellular ADP-ribosylation machinery.