Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endoso...

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Bibliographic Details
Main Authors: Amika Singla, Alina Fedoseienko, Sai S. P. Giridharan, Brittany L. Overlee, Adam Lopez, Da Jia, Jie Song, Kayci Huff-Hardy, Lois Weisman, Ezra Burstein, Daniel D. Billadeau
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/05e31276e2a744fdb7699f4e17f5be4d
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Summary:Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endosomal membranes.

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