Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endoso...

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Auteurs principaux:	Amika Singla, Alina Fedoseienko, Sai S. P. Giridharan, Brittany L. Overlee, Adam Lopez, Da Jia, Jie Song, Kayci Huff-Hardy, Lois Weisman, Ezra Burstein, Daniel D. Billadeau
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/05e31276e2a744fdb7699f4e17f5be4d
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spelling	oai:doaj.org-article:05e31276e2a744fdb7699f4e17f5be4d2021-12-02T15:35:07ZEndosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling10.1038/s41467-019-12221-62041-1723https://doaj.org/article/05e31276e2a744fdb7699f4e17f5be4d2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12221-6https://doaj.org/toc/2041-1723Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endosomal membranes.Amika SinglaAlina FedoseienkoSai S. P. GiridharanBrittany L. OverleeAdam LopezDa JiaJie SongKayci Huff-HardyLois WeismanEzra BursteinDaniel D. BilladeauNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amika Singla Alina Fedoseienko Sai S. P. Giridharan Brittany L. Overlee Adam Lopez Da Jia Jie Song Kayci Huff-Hardy Lois Weisman Ezra Burstein Daniel D. Billadeau Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling
description	Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endosomal membranes.
format	article
author	Amika Singla Alina Fedoseienko Sai S. P. Giridharan Brittany L. Overlee Adam Lopez Da Jia Jie Song Kayci Huff-Hardy Lois Weisman Ezra Burstein Daniel D. Billadeau
author_facet	Amika Singla Alina Fedoseienko Sai S. P. Giridharan Brittany L. Overlee Adam Lopez Da Jia Jie Song Kayci Huff-Hardy Lois Weisman Ezra Burstein Daniel D. Billadeau
author_sort	Amika Singla
title	Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling
title_short	Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling
title_full	Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling
title_fullStr	Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling
title_full_unstemmed	Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling
title_sort	endosomal pi(3)p regulation by the commd/ccdc22/ccdc93 (ccc) complex controls membrane protein recycling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/05e31276e2a744fdb7699f4e17f5be4d
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Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

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