Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.

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Detalles Bibliográficos
Autores principales: Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
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https://doaj.org/article/063c642bedca45fb8d0878850da6e48f

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