Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.

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Autores principales:	Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
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spelling	oai:doaj.org-article:063c642bedca45fb8d0878850da6e48f2021-12-02T17:31:39ZChemical modifications of adenine base editor mRNA and guide RNA expand its application scope10.1038/s41467-020-15892-82041-1723https://doaj.org/article/063c642bedca45fb8d0878850da6e48f2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15892-8https://doaj.org/toc/2041-1723Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.Tingting JiangJordana M. HendersonKevin CooteYi ChengHillary C. ValleyXiao-Ou ZhangQin WangLuke H. RhymYueying CaoGregory A. NewbyHermann BihlerMartin MenseZhiping WengDaniel G. AndersonAnton P. McCaffreyDavid R. LiuWen XueNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tingting Jiang Jordana M. Henderson Kevin Coote Yi Cheng Hillary C. Valley Xiao-Ou Zhang Qin Wang Luke H. Rhym Yueying Cao Gregory A. Newby Hermann Bihler Martin Mense Zhiping Weng Daniel G. Anderson Anton P. McCaffrey David R. Liu Wen Xue Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
description	Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.
format	article
author	Tingting Jiang Jordana M. Henderson Kevin Coote Yi Cheng Hillary C. Valley Xiao-Ou Zhang Qin Wang Luke H. Rhym Yueying Cao Gregory A. Newby Hermann Bihler Martin Mense Zhiping Weng Daniel G. Anderson Anton P. McCaffrey David R. Liu Wen Xue
author_facet	Tingting Jiang Jordana M. Henderson Kevin Coote Yi Cheng Hillary C. Valley Xiao-Ou Zhang Qin Wang Luke H. Rhym Yueying Cao Gregory A. Newby Hermann Bihler Martin Mense Zhiping Weng Daniel G. Anderson Anton P. McCaffrey David R. Liu Wen Xue
author_sort	Tingting Jiang
title	Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
title_short	Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
title_full	Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
title_fullStr	Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
title_full_unstemmed	Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
title_sort	chemical modifications of adenine base editor mrna and guide rna expand its application scope
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

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