Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.

Guardado en:
Detalles Bibliográficos
Autores principales: Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares