A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

Synthetic biology offers the potential for the design and implementation of rationally designed, complex genetic programmes. Here the authors design a genetic network to trigger the differentiation of patient derived IPSCs into beta-like cells.

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Autores principales: Pratik Saxena, Boon Chin Heng, Peng Bai, Marc Folcher, Henryk Zulewski, Martin Fussenegger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/066ccf7797a74348a01c165392480612
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spelling oai:doaj.org-article:066ccf7797a74348a01c1653924806122021-12-02T14:38:55ZA programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells10.1038/ncomms112472041-1723https://doaj.org/article/066ccf7797a74348a01c1653924806122016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11247https://doaj.org/toc/2041-1723Synthetic biology offers the potential for the design and implementation of rationally designed, complex genetic programmes. Here the authors design a genetic network to trigger the differentiation of patient derived IPSCs into beta-like cells.Pratik SaxenaBoon Chin HengPeng BaiMarc FolcherHenryk ZulewskiMartin FusseneggerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Pratik Saxena
Boon Chin Heng
Peng Bai
Marc Folcher
Henryk Zulewski
Martin Fussenegger
A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
description Synthetic biology offers the potential for the design and implementation of rationally designed, complex genetic programmes. Here the authors design a genetic network to trigger the differentiation of patient derived IPSCs into beta-like cells.
format article
author Pratik Saxena
Boon Chin Heng
Peng Bai
Marc Folcher
Henryk Zulewski
Martin Fussenegger
author_facet Pratik Saxena
Boon Chin Heng
Peng Bai
Marc Folcher
Henryk Zulewski
Martin Fussenegger
author_sort Pratik Saxena
title A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
title_short A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
title_full A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
title_fullStr A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
title_full_unstemmed A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
title_sort programmable synthetic lineage-control network that differentiates human ipscs into glucose-sensitive insulin-secreting beta-like cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/066ccf7797a74348a01c165392480612
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