A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

Synthetic biology offers the potential for the design and implementation of rationally designed, complex genetic programmes. Here the authors design a genetic network to trigger the differentiation of patient derived IPSCs into beta-like cells.

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Detalles Bibliográficos
Autores principales: Pratik Saxena, Boon Chin Heng, Peng Bai, Marc Folcher, Henryk Zulewski, Martin Fussenegger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/066ccf7797a74348a01c165392480612
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