Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B

Resistance towards VEGF-centered anti-angiogenic therapy is an important clinical challenge. Here, the authors show that mast cells mediate resistance to anti-angiogenetic inhibitors by altering the proliferative and organizational state of endothelial cells through mobilization of FGF-1 and GM-CSF...

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Main Authors: M. Wroblewski, R. Bauer, M. Cubas Córdova, F. Udonta, I. Ben-Batalla, K. Legler, C. Hauser, J. Egberts, M. Janning, J. Velthaus, C. Schulze, K. Pantel, C. Bokemeyer, S. Loges
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/0675e6e7e74141089122b663eb98619e
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