Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B

Resistance towards VEGF-centered anti-angiogenic therapy is an important clinical challenge. Here, the authors show that mast cells mediate resistance to anti-angiogenetic inhibitors by altering the proliferative and organizational state of endothelial cells through mobilization of FGF-1 and GM-CSF...

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Autores principales:	M. Wroblewski, R. Bauer, M. Cubas Córdova, F. Udonta, I. Ben-Batalla, K. Legler, C. Hauser, J. Egberts, M. Janning, J. Velthaus, C. Schulze, K. Pantel, C. Bokemeyer, S. Loges
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0675e6e7e74141089122b663eb98619e
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spelling	oai:doaj.org-article:0675e6e7e74141089122b663eb98619e2021-12-02T14:16:04ZMast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B10.1038/s41467-017-00327-82041-1723https://doaj.org/article/0675e6e7e74141089122b663eb98619e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00327-8https://doaj.org/toc/2041-1723Resistance towards VEGF-centered anti-angiogenic therapy is an important clinical challenge. Here, the authors show that mast cells mediate resistance to anti-angiogenetic inhibitors by altering the proliferative and organizational state of endothelial cells through mobilization of FGF-1 and GM-CSF from the tumor matrix and secretion of FGF-2.M. WroblewskiR. BauerM. Cubas CórdovaF. UdontaI. Ben-BatallaK. LeglerC. HauserJ. EgbertsM. JanningJ. VelthausC. SchulzeK. PantelC. BokemeyerS. LogesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Wroblewski R. Bauer M. Cubas Córdova F. Udonta I. Ben-Batalla K. Legler C. Hauser J. Egberts M. Janning J. Velthaus C. Schulze K. Pantel C. Bokemeyer S. Loges Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
description	Resistance towards VEGF-centered anti-angiogenic therapy is an important clinical challenge. Here, the authors show that mast cells mediate resistance to anti-angiogenetic inhibitors by altering the proliferative and organizational state of endothelial cells through mobilization of FGF-1 and GM-CSF from the tumor matrix and secretion of FGF-2.
format	article
author	M. Wroblewski R. Bauer M. Cubas Córdova F. Udonta I. Ben-Batalla K. Legler C. Hauser J. Egberts M. Janning J. Velthaus C. Schulze K. Pantel C. Bokemeyer S. Loges
author_facet	M. Wroblewski R. Bauer M. Cubas Córdova F. Udonta I. Ben-Batalla K. Legler C. Hauser J. Egberts M. Janning J. Velthaus C. Schulze K. Pantel C. Bokemeyer S. Loges
author_sort	M. Wroblewski
title	Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
title_short	Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
title_full	Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
title_fullStr	Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
title_full_unstemmed	Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
title_sort	mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme b
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0675e6e7e74141089122b663eb98619e
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Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B

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