Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in vitro osteoblast differentiation experiments.

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Auteurs principaux: Alessandra Chesi, Yadav Wagley, Matthew E. Johnson, Elisabetta Manduchi, Chun Su, Sumei Lu, Michelle E. Leonard, Kenyaita M. Hodge, James A. Pippin, Kurt D. Hankenson, Andrew D. Wells, Struan F. A. Grant
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Science
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Accès en ligne:https://doaj.org/article/068349a3f36f4d3abaa72dceb7f71f4a
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https://doaj.org/article/068349a3f36f4d3abaa72dceb7f71f4a

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