Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in vitro osteoblast differentiation experiments.

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Autores principales:	Alessandra Chesi, Yadav Wagley, Matthew E. Johnson, Elisabetta Manduchi, Chun Su, Sumei Lu, Michelle E. Leonard, Kenyaita M. Hodge, James A. Pippin, Kurt D. Hankenson, Andrew D. Wells, Struan F. A. Grant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/068349a3f36f4d3abaa72dceb7f71f4a
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spelling	oai:doaj.org-article:068349a3f36f4d3abaa72dceb7f71f4a2021-12-02T15:35:39ZGenome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density10.1038/s41467-019-09302-x2041-1723https://doaj.org/article/068349a3f36f4d3abaa72dceb7f71f4a2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09302-xhttps://doaj.org/toc/2041-1723GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in vitro osteoblast differentiation experiments.Alessandra ChesiYadav WagleyMatthew E. JohnsonElisabetta ManduchiChun SuSumei LuMichelle E. LeonardKenyaita M. HodgeJames A. PippinKurt D. HankensonAndrew D. WellsStruan F. A. GrantNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandra Chesi Yadav Wagley Matthew E. Johnson Elisabetta Manduchi Chun Su Sumei Lu Michelle E. Leonard Kenyaita M. Hodge James A. Pippin Kurt D. Hankenson Andrew D. Wells Struan F. A. Grant Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
description	GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in vitro osteoblast differentiation experiments.
format	article
author	Alessandra Chesi Yadav Wagley Matthew E. Johnson Elisabetta Manduchi Chun Su Sumei Lu Michelle E. Leonard Kenyaita M. Hodge James A. Pippin Kurt D. Hankenson Andrew D. Wells Struan F. A. Grant
author_facet	Alessandra Chesi Yadav Wagley Matthew E. Johnson Elisabetta Manduchi Chun Su Sumei Lu Michelle E. Leonard Kenyaita M. Hodge James A. Pippin Kurt D. Hankenson Andrew D. Wells Struan F. A. Grant
author_sort	Alessandra Chesi
title	Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
title_short	Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
title_full	Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
title_fullStr	Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
title_full_unstemmed	Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
title_sort	genome-scale capture c promoter interactions implicate effector genes at gwas loci for bone mineral density
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/068349a3f36f4d3abaa72dceb7f71f4a
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Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

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