ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules. Previously, we have shown that genetic or pharmacological inhibition of ERAP1 on murine and human tumor cel...

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Autores principales: Silvia D’Amico, Valerio D’Alicandro, Mirco Compagnone, Patrizia Tempora, Giusy Guida, Paolo Romania, Valeria Lucarini, Ombretta Melaiu, Michela Falco, Mattia Algeri, Daniela Pende, Loredana Cifaldi, Doriana Fruci
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
ERAP1
NK cells
NK cell immunotherapy
HLA class I
KIR
cancer
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/06850dcc2f5e4212b15a4f9dfffcba72
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https://doaj.org/article/06850dcc2f5e4212b15a4f9dfffcba72

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