Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden Syrian hamster model of infection while showing...

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Autores principales:	Qi Zhang, Bin Ju, Jiwan Ge, Jasper Fuk-Woo Chan, Lin Cheng, Ruoke Wang, Weijin Huang, Mengqi Fang, Peng Chen, Bing Zhou, Shuo Song, Sisi Shan, Baohua Yan, Senyan Zhang, Xiangyang Ge, Jiazhen Yu, Juanjuan Zhao, Haiyan Wang, Li Liu, Qining Lv, Lili Fu, Xuanling Shi, Kwok Yung Yuen, Lei Liu, Youchun Wang, Zhiwei Chen, Linqi Zhang, Xinquan Wang, Zheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/068df09610874565a1ef7f05fbef6c89
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:068df09610874565a1ef7f05fbef6c892021-12-02T15:40:02ZPotent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-210.1038/s41467-021-24514-w2041-1723https://doaj.org/article/068df09610874565a1ef7f05fbef6c892021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24514-whttps://doaj.org/toc/2041-1723Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden Syrian hamster model of infection while showing the emergence of mutations at position 417 of the Spike protein that confer resistance.Qi ZhangBin JuJiwan GeJasper Fuk-Woo ChanLin ChengRuoke WangWeijin HuangMengqi FangPeng ChenBing ZhouShuo SongSisi ShanBaohua YanSenyan ZhangXiangyang GeJiazhen YuJuanjuan ZhaoHaiyan WangLi LiuQining LvLili FuXuanling ShiKwok Yung YuenLei LiuYouchun WangZhiwei ChenLinqi ZhangXinquan WangZheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qi Zhang Bin Ju Jiwan Ge Jasper Fuk-Woo Chan Lin Cheng Ruoke Wang Weijin Huang Mengqi Fang Peng Chen Bing Zhou Shuo Song Sisi Shan Baohua Yan Senyan Zhang Xiangyang Ge Jiazhen Yu Juanjuan Zhao Haiyan Wang Li Liu Qining Lv Lili Fu Xuanling Shi Kwok Yung Yuen Lei Liu Youchun Wang Zhiwei Chen Linqi Zhang Xinquan Wang Zheng Zhang Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
description	Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden Syrian hamster model of infection while showing the emergence of mutations at position 417 of the Spike protein that confer resistance.
format	article
author	Qi Zhang Bin Ju Jiwan Ge Jasper Fuk-Woo Chan Lin Cheng Ruoke Wang Weijin Huang Mengqi Fang Peng Chen Bing Zhou Shuo Song Sisi Shan Baohua Yan Senyan Zhang Xiangyang Ge Jiazhen Yu Juanjuan Zhao Haiyan Wang Li Liu Qining Lv Lili Fu Xuanling Shi Kwok Yung Yuen Lei Liu Youchun Wang Zhiwei Chen Linqi Zhang Xinquan Wang Zheng Zhang
author_facet	Qi Zhang Bin Ju Jiwan Ge Jasper Fuk-Woo Chan Lin Cheng Ruoke Wang Weijin Huang Mengqi Fang Peng Chen Bing Zhou Shuo Song Sisi Shan Baohua Yan Senyan Zhang Xiangyang Ge Jiazhen Yu Juanjuan Zhao Haiyan Wang Li Liu Qining Lv Lili Fu Xuanling Shi Kwok Yung Yuen Lei Liu Youchun Wang Zhiwei Chen Linqi Zhang Xinquan Wang Zheng Zhang
author_sort	Qi Zhang
title	Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
title_short	Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
title_full	Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
title_fullStr	Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
title_full_unstemmed	Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
title_sort	potent and protective ighv3-53/3-66 public antibodies and their shared escape mutant on the spike of sars-cov-2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/068df09610874565a1ef7f05fbef6c89
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Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

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