Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Gene rv3722c is essential for in vitro growth of Mycobacterium tuberculosis, but its function is unclear. Here, Jansen et al. show that Rv3722c is the primary aspartate aminotransferase of this pathogen, mediates nitrogen distribution, and is important for virulence during infection of macrophages a...

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Autores principales:	Robert S. Jansen, Lungelo Mandyoli, Ryan Hughes, Shoko Wakabayashi, Jessica T. Pinkham, Bruna Selbach, Kristine M. Guinn, Eric J. Rubin, James C. Sacchettini, Kyu Y. Rhee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0694e638b1514ac5a6f5150aca969407
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spelling	oai:doaj.org-article:0694e638b1514ac5a6f5150aca9694072021-12-02T14:42:15ZAspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis10.1038/s41467-020-15876-82041-1723https://doaj.org/article/0694e638b1514ac5a6f5150aca9694072020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15876-8https://doaj.org/toc/2041-1723Gene rv3722c is essential for in vitro growth of Mycobacterium tuberculosis, but its function is unclear. Here, Jansen et al. show that Rv3722c is the primary aspartate aminotransferase of this pathogen, mediates nitrogen distribution, and is important for virulence during infection of macrophages and mice.Robert S. JansenLungelo MandyoliRyan HughesShoko WakabayashiJessica T. PinkhamBruna SelbachKristine M. GuinnEric J. RubinJames C. SacchettiniKyu Y. RheeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert S. Jansen Lungelo Mandyoli Ryan Hughes Shoko Wakabayashi Jessica T. Pinkham Bruna Selbach Kristine M. Guinn Eric J. Rubin James C. Sacchettini Kyu Y. Rhee Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
description	Gene rv3722c is essential for in vitro growth of Mycobacterium tuberculosis, but its function is unclear. Here, Jansen et al. show that Rv3722c is the primary aspartate aminotransferase of this pathogen, mediates nitrogen distribution, and is important for virulence during infection of macrophages and mice.
format	article
author	Robert S. Jansen Lungelo Mandyoli Ryan Hughes Shoko Wakabayashi Jessica T. Pinkham Bruna Selbach Kristine M. Guinn Eric J. Rubin James C. Sacchettini Kyu Y. Rhee
author_facet	Robert S. Jansen Lungelo Mandyoli Ryan Hughes Shoko Wakabayashi Jessica T. Pinkham Bruna Selbach Kristine M. Guinn Eric J. Rubin James C. Sacchettini Kyu Y. Rhee
author_sort	Robert S. Jansen
title	Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
title_short	Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
title_full	Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
title_fullStr	Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
title_full_unstemmed	Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
title_sort	aspartate aminotransferase rv3722c governs aspartate-dependent nitrogen metabolism in mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0694e638b1514ac5a6f5150aca969407
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Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

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