Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture

How CD8+ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8+ T c...

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Autores principales: Qiang Shan, Xiang Li, Xia Chen, Zhouhao Zeng, Shaoqi Zhu, Kexin Gai, Weiqun Peng, Hai-Hui Xue
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/06c9799f7b944534ab901ab6e4e9438f
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