Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture

How CD8+ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8+ T c...

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Autores principales:	Qiang Shan, Xiang Li, Xia Chen, Zhouhao Zeng, Shaoqi Zhu, Kexin Gai, Weiqun Peng, Hai-Hui Xue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06c9799f7b944534ab901ab6e4e9438f
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id	oai:doaj.org-article:06c9799f7b944534ab901ab6e4e9438f
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spelling	oai:doaj.org-article:06c9799f7b944534ab901ab6e4e9438f2021-12-02T17:13:18ZTcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture10.1038/s41467-021-26159-12041-1723https://doaj.org/article/06c9799f7b944534ab901ab6e4e9438f2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26159-1https://doaj.org/toc/2041-1723How CD8+ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8+ T cells.Qiang ShanXiang LiXia ChenZhouhao ZengShaoqi ZhuKexin GaiWeiqun PengHai-Hui XueNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiang Shan Xiang Li Xia Chen Zhouhao Zeng Shaoqi Zhu Kexin Gai Weiqun Peng Hai-Hui Xue Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
description	How CD8+ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8+ T cells.
format	article
author	Qiang Shan Xiang Li Xia Chen Zhouhao Zeng Shaoqi Zhu Kexin Gai Weiqun Peng Hai-Hui Xue
author_facet	Qiang Shan Xiang Li Xia Chen Zhouhao Zeng Shaoqi Zhu Kexin Gai Weiqun Peng Hai-Hui Xue
author_sort	Qiang Shan
title	Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
title_short	Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
title_full	Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
title_fullStr	Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
title_full_unstemmed	Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
title_sort	tcf1 and lef1 provide constant supervision to mature cd8+ t cell identity and function by organizing genomic architecture
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06c9799f7b944534ab901ab6e4e9438f
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Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture

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