<italic toggle="yes">Plasmodium falciparum</italic> K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness <italic toggle="yes">In Vitro</italic>

<italic toggle="yes">Plasmodium falciparum</italic> K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness <italic toggle="yes">In Vitro</italic>

ABSTRACT The emergence and spread in Southeast Asia of Plasmodium falciparum resistance to artemisinin (ART) derivatives, the cornerstone of first-line artemisinin-based combination therapies (ACTs), underscore the urgent need to identify suitable replacement drugs. Discovery and development efforts...

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Autores principales: Judith Straimer, Nina F. Gnädig, Barbara H. Stokes, Michelle Ehrenberger, Audrey A. Crane, David A. Fidock
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
K13/Kelch13
Plasmodium falciparum
artemisinin
drug resistance
fitness
gene editing
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/06d30e8ca91e4ac9a14623a11fde6b7e
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