Hemozoin Promotes Lung Inflammation via Host Epithelial Activation

por Shivang S. Shah, David A. Fidock, Alice S. Prince
Publicado 2021

Malaria's missing number: calculating the human component of R0 by a within-host mechanistic model of Plasmodium falciparum infection and transmission.

por Geoffrey L Johnston, David L Smith, David A Fidock
Publicado 2013

Modeling within-host effects of drugs on Plasmodium falciparum transmission and prospects for malaria elimination.

por Geoffrey L Johnston, Peter W Gething, Simon I Hay, David L Smith, David A Fidock
Publicado 2014

<italic toggle="yes">Plasmodium falciparum</italic> K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness <italic toggle="yes">In Vitro</italic>

por Judith Straimer, Nina F. Gnädig, Barbara H. Stokes, Michelle Ehrenberger, Audrey A. Crane, David A. Fidock
Publicado 2017

<named-content content-type="genus-species">Plasmodium berghei</named-content> K13 Mutations Mediate <italic toggle="yes">In Vivo</italic> Artemisinin Resistance That Is Reversed b...

por Nelson V. Simwela, Barbara H. Stokes, Dana Aghabi, Matt Bogyo, David A. Fidock, Andrew P. Waters
Publicado 2020

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

por Stephanie G Valderramos, Juan-Carlos Valderramos, Lise Musset, Lisa A Purcell, Odile Mercereau-Puijalon, Eric Legrand, David A Fidock
Publicado 2010

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on <named-content content-type="genus-species">Plasmodium falciparum</named-content> Multidrug Resistance and Fitness

por Satish K. Dhingra, Stanislaw J. Gabryszewski, Jennifer L. Small-Saunders, Tomas Yeo, Philipp P. Henrich, Sachel Mok, David A. Fidock
Publicado 2019

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

por M. Isabel Veiga, Satish K. Dhingra, Philipp P. Henrich, Judith Straimer, Nina Gnädig, Anne-Catrin Uhlemann, Rowena E. Martin, Adele M. Lehane, David A. Fidock
Publicado 2016

Expansion of a Specific <named-content content-type="genus-species">Plasmodium falciparum</named-content> PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport

por Carla Calçada, Miguel Silva, Vitória Baptista, Vandana Thathy, Rita Silva-Pedrosa, Diana Granja, Pedro Eduardo Ferreira, José Pedro Gil, David A. Fidock, Maria Isabel Veiga
Publicado 2020

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

por Leila S. Ross, Satish K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, Benoit Witkowski, Rick M. Fairhurst, Frederic Ariey, Didier Menard, David A. Fidock
Publicado 2018

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

por Clare R. Harding, Saima M. Sidik, Boryana Petrova, Nina F. Gnädig, John Okombo, Alice L. Herneisen, Kurt E. Ward, Benedikt M. Markus, Elizabeth A. Boydston, David A. Fidock, Sebastian Lourido
Publicado 2020

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

por Sachel Mok, Barbara H. Stokes, Nina F. Gnädig, Leila S. Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R. Bottrill, Jaishree Tripathi, Rick M. Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B. Tobin, David A. Fidock
Publicado 2021

A Variant PfCRT Isoform Can Contribute to <italic toggle="yes">Plasmodium falciparum</italic> Resistance to the First-Line Partner Drug Piperaquine

por Satish K. Dhingra, Devasha Redhi, Jill M. Combrinck, Tomas Yeo, John Okombo, Philipp P. Henrich, Annie N. Cowell, Purva Gupta, Matthew L. Stegman, Jonathan M. Hoke, Roland A. Cooper, Elizabeth Winzeler, Sachel Mok, Timothy J. Egan, David A. Fidock
Publicado 2017

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters

por Kyle Jarrod McLean, Judith Straimer, Christine S. Hopp, Joel Vega-Rodriguez, Jennifer L. Small-Saunders, Sachie Kanatani, Abhai Tripathi, Godfree Mlambo, Peter C. Dumoulin, Chantal T. Harris, Xinran Tong, Melanie J. Shears, Johan Ankarklev, Björn F. C. Kafsack, David A. Fidock, Photini Sinnis
Publicado 2019

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

por Evelien M. Bunnik, Kate B. Cook, Nelle Varoquaux, Gayani Batugedara, Jacques Prudhomme, Anthony Cort, Lirong Shi, Chiara Andolina, Leila S. Ross, Declan Brady, David A. Fidock, Francois Nosten, Rita Tewari, Photini Sinnis, Ferhat Ay, Jean-Philippe Vert, William Stafford Noble, Karine G. Le Roch
Publicado 2018

The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957

por Celia Miguel-Blanco, James M. Murithi, Ernest Diez Benavente, Fiona Angrisano, Katarzyna A. Sala, Donelly A. van Schalkwyk, Manu Vanaerschot, Frank Schwach, Matthew J. Fuchter, Oliver Billker, Colin J. Sutherland, Susana G. Campino, Taane G. Clark, Andrew M. Blagborough, David A. Fidock, Esperanza Herreros, Francisco Javier Gamo, Jake Baum, Michael J. Delves
Publicado 2021

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

por Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M. R. K. Alley, Vida Ahyong, Laura M. Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiri Gut, Jenny Legac, Roland A. Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R. Freund, David A. Fidock, Philip J. Rosenthal
Publicado 2017

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

por Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler
Publicado 2020

A broad analysis of resistance development in the malaria parasite

por Victoria C. Corey, Amanda K. Lukens, Eva S. Istvan, Marcus C. S. Lee, Virginia Franco, Pamela Magistrado, Olivia Coburn-Flynn, Tomoyo Sakata-Kato, Olivia Fuchs, Nina F. Gnädig, Greg Goldgof, Maria Linares, Maria G. Gomez-Lorenzo, Cristina De Cózar, Maria Jose Lafuente-Monasterio, Sara Prats, Stephan Meister, Olga Tanaseichuk, Melanie Wree, Yingyao Zhou, Paul A. Willis, Francisco-Javier Gamo, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler
Publicado 2016

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites

por Dorjbal Dorjsuren, Richard T. Eastman, Kathryn J. Wicht, Daniel Jansen, Daniel C. Talley, Benjamin A. Sigmon, Alexey V. Zakharov, Norma Roncal, Andrew T. Girvin, Yevgeniya Antonova-Koch, Paul M. Will, Pranav Shah, Hongmao Sun, Carleen Klumpp-Thomas, Sachel Mok, Tomas Yeo, Stephan Meister, Juan Jose Marugan, Leila S. Ross, Xin Xu, David J. Maloney, Ajit Jadhav, Bryan T. Mott, Richard J. Sciotti, Elizabeth A. Winzeler, Norman C. Waters, Robert F. Campbell, Wenwei Huang, Anton Simeonov, David A. Fidock
Publicado 2021