Homeostasis of protein and mRNA concentrations in growing cells

For various organisms, mRNA and protein copy numbers scale with cell volume. Here, the authors show that this result emerges naturally when ribosomes and RNAPs limit expression. Furthermore, the authors show that within their model this result breaks down for a sufficiently high volume/DNA ratio.

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Detalles Bibliográficos
Autores principales: Jie Lin, Ariel Amir
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/07071b8a4c344088b8de776b0ef66c66
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