Homeostasis of protein and mRNA concentrations in growing cells

For various organisms, mRNA and protein copy numbers scale with cell volume. Here, the authors show that this result emerges naturally when ribosomes and RNAPs limit expression. Furthermore, the authors show that within their model this result breaks down for a sufficiently high volume/DNA ratio.

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Detalles Bibliográficos
Autores principales:	Jie Lin, Ariel Amir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07071b8a4c344088b8de776b0ef66c66
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spelling	oai:doaj.org-article:07071b8a4c344088b8de776b0ef66c662021-12-02T16:56:53ZHomeostasis of protein and mRNA concentrations in growing cells10.1038/s41467-018-06714-z2041-1723https://doaj.org/article/07071b8a4c344088b8de776b0ef66c662018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06714-zhttps://doaj.org/toc/2041-1723For various organisms, mRNA and protein copy numbers scale with cell volume. Here, the authors show that this result emerges naturally when ribosomes and RNAPs limit expression. Furthermore, the authors show that within their model this result breaks down for a sufficiently high volume/DNA ratio.Jie LinAriel AmirNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Lin Ariel Amir Homeostasis of protein and mRNA concentrations in growing cells
description	For various organisms, mRNA and protein copy numbers scale with cell volume. Here, the authors show that this result emerges naturally when ribosomes and RNAPs limit expression. Furthermore, the authors show that within their model this result breaks down for a sufficiently high volume/DNA ratio.
format	article
author	Jie Lin Ariel Amir
author_facet	Jie Lin Ariel Amir
author_sort	Jie Lin
title	Homeostasis of protein and mRNA concentrations in growing cells
title_short	Homeostasis of protein and mRNA concentrations in growing cells
title_full	Homeostasis of protein and mRNA concentrations in growing cells
title_fullStr	Homeostasis of protein and mRNA concentrations in growing cells
title_full_unstemmed	Homeostasis of protein and mRNA concentrations in growing cells
title_sort	homeostasis of protein and mrna concentrations in growing cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/07071b8a4c344088b8de776b0ef66c66
work_keys_str_mv	AT jielin homeostasisofproteinandmrnaconcentrationsingrowingcells AT arielamir homeostasisofproteinandmrnaconcentrationsingrowingcells
_version_	1718382663116521472

Homeostasis of protein and mRNA concentrations in growing cells

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