Homeostasis of protein and mRNA concentrations in growing cells
For various organisms, mRNA and protein copy numbers scale with cell volume. Here, the authors show that this result emerges naturally when ribosomes and RNAPs limit expression. Furthermore, the authors show that within their model this result breaks down for a sufficiently high volume/DNA ratio.
Guardado en:
Autores principales: | Jie Lin, Ariel Amir |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/07071b8a4c344088b8de776b0ef66c66 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Publisher Correction: Exploring the effect of network topology, mRNA and protein dynamics on gene regulatory network stability
por: Yipei Guo, et al.
Publicado: (2021) -
Ultra-sensitive digital quantification of proteins and mRNA in single cells
por: Jing Lin, et al.
Publicado: (2019) -
Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
por: Nuphar Veiga, et al.
Publicado: (2018) -
Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells
por: Hailong Zhang, et al.
Publicado: (2021) -
Single-cell, single-mRNA analysis of Ccnb1 promoter regulation
por: Nidhi Vishnoi, et al.
Publicado: (2017)