Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival

Nishinaga et al. present structural characterization of the transcription regulator PefR from S. agalactiae in different states (apo-, DNAbound, heme-bound, CO-heme-bound and CN-heme-bound-PefRs). Structural comparison revealed that unique heme coordination controls structural rearrangement for the...

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Autores principales:	Megumi Nishinaga, Hiroshi Sugimoto, Yudai Nishitani, Seina Nagai, Satoru Nagatoishi, Norifumi Muraki, Takehiko Tosha, Kouhei Tsumoto, Shigetoshi Aono, Yoshitsugu Shiro, Hitomi Sawai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/07128172ea764ecdbc5f4b432580abbb
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spelling	oai:doaj.org-article:07128172ea764ecdbc5f4b432580abbb2021-12-02T14:30:33ZHeme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival10.1038/s42003-021-01987-52399-3642https://doaj.org/article/07128172ea764ecdbc5f4b432580abbb2021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01987-5https://doaj.org/toc/2399-3642Nishinaga et al. present structural characterization of the transcription regulator PefR from S. agalactiae in different states (apo-, DNAbound, heme-bound, CO-heme-bound and CN-heme-bound-PefRs). Structural comparison revealed that unique heme coordination controls structural rearrangement for the survival of the neonatal infection-causing hemolytic bacteria.Megumi NishinagaHiroshi SugimotoYudai NishitaniSeina NagaiSatoru NagatoishiNorifumi MurakiTakehiko ToshaKouhei TsumotoShigetoshi AonoYoshitsugu ShiroHitomi SawaiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Megumi Nishinaga Hiroshi Sugimoto Yudai Nishitani Seina Nagai Satoru Nagatoishi Norifumi Muraki Takehiko Tosha Kouhei Tsumoto Shigetoshi Aono Yoshitsugu Shiro Hitomi Sawai Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
description	Nishinaga et al. present structural characterization of the transcription regulator PefR from S. agalactiae in different states (apo-, DNAbound, heme-bound, CO-heme-bound and CN-heme-bound-PefRs). Structural comparison revealed that unique heme coordination controls structural rearrangement for the survival of the neonatal infection-causing hemolytic bacteria.
format	article
author	Megumi Nishinaga Hiroshi Sugimoto Yudai Nishitani Seina Nagai Satoru Nagatoishi Norifumi Muraki Takehiko Tosha Kouhei Tsumoto Shigetoshi Aono Yoshitsugu Shiro Hitomi Sawai
author_facet	Megumi Nishinaga Hiroshi Sugimoto Yudai Nishitani Seina Nagai Satoru Nagatoishi Norifumi Muraki Takehiko Tosha Kouhei Tsumoto Shigetoshi Aono Yoshitsugu Shiro Hitomi Sawai
author_sort	Megumi Nishinaga
title	Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
title_short	Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
title_full	Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
title_fullStr	Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
title_full_unstemmed	Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
title_sort	heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07128172ea764ecdbc5f4b432580abbb
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Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival

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