Author Correction: Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis

por Shuntaro Chiba, Aki Tanabe, Makoto Nakakido, Yasushi Okuno, Kouhei Tsumoto, Masateru Ohta
Publicado 2021

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

por Hiroki Akiba, Tomoko Ise, Satoshi Nagata, Haruhiko Kamada, Hiroaki Ohno, Kouhei Tsumoto
Publicado 2021

Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support

por Toshihiro Ito, Takeharu Minamitani, Masaki Hayakawa, Ryota Otsubo, Hiroki Akiba, Kouhei Tsumoto, Masanori Matsumoto, Teruhito Yasui
Publicado 2021

A glutamine sensor that directly activates TORC1

por Mirai Tanigawa, Katsuyoshi Yamamoto, Satoru Nagatoishi, Koji Nagata, Daisuke Noshiro, Nobuo N. Noda, Kouhei Tsumoto, Tatsuya Maeda
Publicado 2021

Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-ant...

por Masato Kiyoshi, Jose M M Caaveiro, Eri Miura, Satoru Nagatoishi, Makoto Nakakido, Shinji Soga, Hiroki Shirai, Shigeki Kawabata, Kouhei Tsumoto
Publicado 2014

Novel neutralizing human monoclonal antibodies against tetanus neurotoxin

por Takeharu Minamitani, Karin Kiyose, Ryota Otsubo, Toshihiro Ito, Hiroki Akiba, Rika A. Furuta, Tsuyoshi Inoue, Kouhei Tsumoto, Masahiro Satake, Teruhito Yasui
Publicado 2021

Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope

por Koki Makabe, Takeshi Yokoyama, Shiro Uehara, Tomomi Uchikubo-Kamo, Mikako Shirouzu, Kouki Kimura, Kouhei Tsumoto, Ryutaro Asano, Yoshikazu Tanaka, Izumi Kumagai
Publicado 2021

Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion

por Akinobu Senoo, Sho Ito, Satoru Nagatoishi, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando, Kouhei Tsumoto
Publicado 2021

Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival

por Megumi Nishinaga, Hiroshi Sugimoto, Yudai Nishitani, Seina Nagai, Satoru Nagatoishi, Norifumi Muraki, Takehiko Tosha, Kouhei Tsumoto, Shigetoshi Aono, Yoshitsugu Shiro, Hitomi Sawai
Publicado 2021

Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction

por Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto, Shinsuke Sando
Publicado 2019

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis

por Motohiro Sekiya, Kenta Kainoh, Takehito Sugasawa, Ryunosuke Yoshino, Takatsugu Hirokawa, Hiroaki Tokiwa, Shogo Nakano, Satoru Nagatoishi, Kouhei Tsumoto, Yoshinori Takeuchi, Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano
Publicado 2021

A secondary RET mutation in the activation loop conferring resistance to vandetanib

por Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald, Koichi Goto
Publicado 2018