The Extracellular Domain of the β<sub>2</sub> Integrin β Subunit (CD18) Is Sufficient for <named-content content-type="genus-species">Escherichia coli</named-content> Hemolysin and <named-content content-type="genus-species">Aggregatibacter actinomycetemcomitans</named-content> Leukotoxin Cytotoxic Activity

The Extracellular Domain of the β<sub>2</sub> Integrin β Subunit (CD18) Is Sufficient for <named-content content-type="genus-species">Escherichia coli</named-content> Hemolysin and <named-content content-type="genus-species">Aggregatibacter actinomycetemcomitans</named-content> Leukotoxin Cytotoxic Activity

ABSTRACT The Escherichia coli hemolysin (HlyA) is a pore-forming exotoxin associated with severe complications of human urinary tract infections. HlyA is the prototype of the repeats-in-toxin (RTX) family, which includes LtxA from Aggregatibacter actinomycetemcomitans, a periodontal pathogen. The ex...

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Bibliographic Details
Main Authors: Laura C. Ristow, Vy Tran, Kevin J. Schwartz, Lillie Pankratz, Andrew Mehle, John-Demian Sauer, Rodney A. Welch
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
cytotoxicity
hemolysin
integrins
leukotoxin
RTX toxin
Microbiology
QR1-502
Online Access:https://doaj.org/article/07258d37f51446f99ca294545c1ad19d
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