A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

Immune system participates in the development of high blood pressure. Here the authors show that cholinergic-sympathetic pathway mediated by the α7nAChR receptor and the activation of splenic T cells prime immunity during hypertension and that selective splenic denervation protects against the onset...

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Autores principales:	Daniela Carnevale, Marialuisa Perrotta, Fabio Pallante, Valentina Fardella, Roberta Iacobucci, Stefania Fardella, Lorenzo Carnevale, Raimondo Carnevale, Massimiliano De Lucia, Giuseppe Cifelli, Giuseppe Lembo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07720ecca2404dfe8b4fc0ece093e54a
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spelling	oai:doaj.org-article:07720ecca2404dfe8b4fc0ece093e54a2021-12-02T17:33:06ZA cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication10.1038/ncomms130352041-1723https://doaj.org/article/07720ecca2404dfe8b4fc0ece093e54a2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms13035https://doaj.org/toc/2041-1723Immune system participates in the development of high blood pressure. Here the authors show that cholinergic-sympathetic pathway mediated by the α7nAChR receptor and the activation of splenic T cells prime immunity during hypertension and that selective splenic denervation protects against the onset of hypertension in mice.Daniela CarnevaleMarialuisa PerrottaFabio PallanteValentina FardellaRoberta IacobucciStefania FardellaLorenzo CarnevaleRaimondo CarnevaleMassimiliano De LuciaGiuseppe CifelliGiuseppe LemboNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniela Carnevale Marialuisa Perrotta Fabio Pallante Valentina Fardella Roberta Iacobucci Stefania Fardella Lorenzo Carnevale Raimondo Carnevale Massimiliano De Lucia Giuseppe Cifelli Giuseppe Lembo A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
description	Immune system participates in the development of high blood pressure. Here the authors show that cholinergic-sympathetic pathway mediated by the α7nAChR receptor and the activation of splenic T cells prime immunity during hypertension and that selective splenic denervation protects against the onset of hypertension in mice.
format	article
author	Daniela Carnevale Marialuisa Perrotta Fabio Pallante Valentina Fardella Roberta Iacobucci Stefania Fardella Lorenzo Carnevale Raimondo Carnevale Massimiliano De Lucia Giuseppe Cifelli Giuseppe Lembo
author_facet	Daniela Carnevale Marialuisa Perrotta Fabio Pallante Valentina Fardella Roberta Iacobucci Stefania Fardella Lorenzo Carnevale Raimondo Carnevale Massimiliano De Lucia Giuseppe Cifelli Giuseppe Lembo
author_sort	Daniela Carnevale
title	A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
title_short	A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
title_full	A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
title_fullStr	A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
title_full_unstemmed	A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
title_sort	cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/07720ecca2404dfe8b4fc0ece093e54a
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A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

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