Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

Abstract X-ray irradiation of high Z elements causes photoelectric effects that include the release of Auger electrons that can induce localized DNA breaks. We have previously established a tumor spheroid-based assay that used gadolinium containing mesoporous silica nanoparticles and synchrotron-gen...

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Autores principales: Yuya Higashi, Kotaro Matsumoto, Hiroyuki Saitoh, Ayumi Shiro, Yue Ma, Mathilde Laird, Shanmugavel Chinnathambi, Albane Birault, Tan Le Hoang Doan, Ryo Yasuda, Toshiki Tajima, Tetsuya Kawachi, Fuyuhiko Tamanoi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0774ae605b3341aab8bffe43ed7857d6
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https://doaj.org/article/0774ae605b3341aab8bffe43ed7857d6

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