Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy

Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM,...

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Autores principales:	Irina S. R. Rio, Ana Rita O. Rodrigues, Juliana M. Rodrigues, Maria-João R. P. Queiroz, R. C. Calhelha, Isabel C. F. R. Ferreira, Bernardo G. Almeida, Ana Pires, André M. Pereira, João P. Araújo, Elisabete M. S. Castanheira, Paulo J. G. Coutinho
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	manganese ferrite/gold nanoparticles magnetoliposomes new antitumor drugs thienopyridine derivatives combined cancer therapy Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/0777f1a3ee694dec82ebd2512c5b589d
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spelling	oai:doaj.org-article:0777f1a3ee694dec82ebd2512c5b589d2021-11-25T18:41:42ZMagnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy10.3390/pharmaceutics131119051999-4923https://doaj.org/article/0777f1a3ee694dec82ebd2512c5b589d2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1905https://doaj.org/toc/1999-4923Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanoparticles was 26.7 nm for MnFe<sub>2</sub>O<sub>4</sub> with 5–7 nm gold nanospheres. The average size of the core/shell nanoparticles was 28.8 nm for the magnetic core and around 4 nm for the gold shell. Two new potential antitumor fluorescent drugs, tricyclic lactones derivatives of thienopyridine, were loaded in these nanosystems with very high encapsulation efficiencies (higher than 98%). Assays in human tumor cell lines demonstrate that the nanocarriers do not release the antitumor compounds in the absence of irradiation. Moreover, the nanosystems do not cause any effect on the growth of primary (non-tumor) cells (with or without irradiation). The drug-loaded systems containing the core/shell magnetic/plasmonic nanoparticles efficiently inhibit the growth of tumor cells when irradiated with red light, making them suitable for a triggered release promoted by irradiation.Irina S. R. RioAna Rita O. RodriguesJuliana M. RodriguesMaria-João R. P. QueirozR. C. CalhelhaIsabel C. F. R. FerreiraBernardo G. AlmeidaAna PiresAndré M. PereiraJoão P. AraújoElisabete M. S. CastanheiraPaulo J. G. CoutinhoMDPI AGarticlemanganese ferrite/gold nanoparticlesmagnetoliposomesnew antitumor drugsthienopyridine derivativescombined cancer therapyPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1905, p 1905 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	manganese ferrite/gold nanoparticles magnetoliposomes new antitumor drugs thienopyridine derivatives combined cancer therapy Pharmacy and materia medica RS1-441
spellingShingle	manganese ferrite/gold nanoparticles magnetoliposomes new antitumor drugs thienopyridine derivatives combined cancer therapy Pharmacy and materia medica RS1-441 Irina S. R. Rio Ana Rita O. Rodrigues Juliana M. Rodrigues Maria-João R. P. Queiroz R. C. Calhelha Isabel C. F. R. Ferreira Bernardo G. Almeida Ana Pires André M. Pereira João P. Araújo Elisabete M. S. Castanheira Paulo J. G. Coutinho Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy
description	Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanoparticles was 26.7 nm for MnFe<sub>2</sub>O<sub>4</sub> with 5–7 nm gold nanospheres. The average size of the core/shell nanoparticles was 28.8 nm for the magnetic core and around 4 nm for the gold shell. Two new potential antitumor fluorescent drugs, tricyclic lactones derivatives of thienopyridine, were loaded in these nanosystems with very high encapsulation efficiencies (higher than 98%). Assays in human tumor cell lines demonstrate that the nanocarriers do not release the antitumor compounds in the absence of irradiation. Moreover, the nanosystems do not cause any effect on the growth of primary (non-tumor) cells (with or without irradiation). The drug-loaded systems containing the core/shell magnetic/plasmonic nanoparticles efficiently inhibit the growth of tumor cells when irradiated with red light, making them suitable for a triggered release promoted by irradiation.
format	article
author	Irina S. R. Rio Ana Rita O. Rodrigues Juliana M. Rodrigues Maria-João R. P. Queiroz R. C. Calhelha Isabel C. F. R. Ferreira Bernardo G. Almeida Ana Pires André M. Pereira João P. Araújo Elisabete M. S. Castanheira Paulo J. G. Coutinho
author_facet	Irina S. R. Rio Ana Rita O. Rodrigues Juliana M. Rodrigues Maria-João R. P. Queiroz R. C. Calhelha Isabel C. F. R. Ferreira Bernardo G. Almeida Ana Pires André M. Pereira João P. Araújo Elisabete M. S. Castanheira Paulo J. G. Coutinho
author_sort	Irina S. R. Rio
title	Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy
title_short	Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy
title_full	Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy
title_fullStr	Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy
title_full_unstemmed	Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy
title_sort	magnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricyclic lactones for combined cancer therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0777f1a3ee694dec82ebd2512c5b589d
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Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy

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