Changes in gene expression predictably shift and switch genetic interactions

Non-additive genetic interactions are plastic and can complicate genetic prediction. Here, using deep mutagenesis of the lambda repressor, Li et al. reveal that changes in gene expression can alter the strength and direction of genetic interactions between mutations in many genes and develop mathema...

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Autores principales: Xianghua Li, Jasna Lalić, Pablo Baeza-Centurion, Riddhiman Dhar, Ben Lehner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/077db6f085c9491fabab07b827951777
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