Changes in gene expression predictably shift and switch genetic interactions

Non-additive genetic interactions are plastic and can complicate genetic prediction. Here, using deep mutagenesis of the lambda repressor, Li et al. reveal that changes in gene expression can alter the strength and direction of genetic interactions between mutations in many genes and develop mathema...

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Autores principales:	Xianghua Li, Jasna Lalić, Pablo Baeza-Centurion, Riddhiman Dhar, Ben Lehner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/077db6f085c9491fabab07b827951777
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spelling	oai:doaj.org-article:077db6f085c9491fabab07b8279517772021-12-02T14:35:30ZChanges in gene expression predictably shift and switch genetic interactions10.1038/s41467-019-11735-32041-1723https://doaj.org/article/077db6f085c9491fabab07b8279517772019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11735-3https://doaj.org/toc/2041-1723Non-additive genetic interactions are plastic and can complicate genetic prediction. Here, using deep mutagenesis of the lambda repressor, Li et al. reveal that changes in gene expression can alter the strength and direction of genetic interactions between mutations in many genes and develop mathematical models for predicting them.Xianghua LiJasna LalićPablo Baeza-CenturionRiddhiman DharBen LehnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xianghua Li Jasna Lalić Pablo Baeza-Centurion Riddhiman Dhar Ben Lehner Changes in gene expression predictably shift and switch genetic interactions
description	Non-additive genetic interactions are plastic and can complicate genetic prediction. Here, using deep mutagenesis of the lambda repressor, Li et al. reveal that changes in gene expression can alter the strength and direction of genetic interactions between mutations in many genes and develop mathematical models for predicting them.
format	article
author	Xianghua Li Jasna Lalić Pablo Baeza-Centurion Riddhiman Dhar Ben Lehner
author_facet	Xianghua Li Jasna Lalić Pablo Baeza-Centurion Riddhiman Dhar Ben Lehner
author_sort	Xianghua Li
title	Changes in gene expression predictably shift and switch genetic interactions
title_short	Changes in gene expression predictably shift and switch genetic interactions
title_full	Changes in gene expression predictably shift and switch genetic interactions
title_fullStr	Changes in gene expression predictably shift and switch genetic interactions
title_full_unstemmed	Changes in gene expression predictably shift and switch genetic interactions
title_sort	changes in gene expression predictably shift and switch genetic interactions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/077db6f085c9491fabab07b827951777
work_keys_str_mv	AT xianghuali changesingeneexpressionpredictablyshiftandswitchgeneticinteractions AT jasnalalic changesingeneexpressionpredictablyshiftandswitchgeneticinteractions AT pablobaezacenturion changesingeneexpressionpredictablyshiftandswitchgeneticinteractions AT riddhimandhar changesingeneexpressionpredictablyshiftandswitchgeneticinteractions AT benlehner changesingeneexpressionpredictablyshiftandswitchgeneticinteractions
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Changes in gene expression predictably shift and switch genetic interactions

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