Metaxins are core components of mitochondrial transport adaptor complexes

Mitochondrial trafficking is carefully regulated and functionally important in neurons. Here, the authors screen C. elegans for abnormal mitochondrial distribution and identify metaxin-1 and -2, which bind Miro and microtubule motor proteins to promote mitochondrial trafficking.

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Autores principales:	Yinsuo Zhao, Eli Song, Wenjuan Wang, Chung-Han Hsieh, Xinnan Wang, Wei Feng, Xiangming Wang, Kang Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0783f54a8c0745b8bb0ac55817195541
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spelling	oai:doaj.org-article:0783f54a8c0745b8bb0ac558171955412021-12-02T15:08:01ZMetaxins are core components of mitochondrial transport adaptor complexes10.1038/s41467-020-20346-22041-1723https://doaj.org/article/0783f54a8c0745b8bb0ac558171955412021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20346-2https://doaj.org/toc/2041-1723Mitochondrial trafficking is carefully regulated and functionally important in neurons. Here, the authors screen C. elegans for abnormal mitochondrial distribution and identify metaxin-1 and -2, which bind Miro and microtubule motor proteins to promote mitochondrial trafficking.Yinsuo ZhaoEli SongWenjuan WangChung-Han HsiehXinnan WangWei FengXiangming WangKang ShenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yinsuo Zhao Eli Song Wenjuan Wang Chung-Han Hsieh Xinnan Wang Wei Feng Xiangming Wang Kang Shen Metaxins are core components of mitochondrial transport adaptor complexes
description	Mitochondrial trafficking is carefully regulated and functionally important in neurons. Here, the authors screen C. elegans for abnormal mitochondrial distribution and identify metaxin-1 and -2, which bind Miro and microtubule motor proteins to promote mitochondrial trafficking.
format	article
author	Yinsuo Zhao Eli Song Wenjuan Wang Chung-Han Hsieh Xinnan Wang Wei Feng Xiangming Wang Kang Shen
author_facet	Yinsuo Zhao Eli Song Wenjuan Wang Chung-Han Hsieh Xinnan Wang Wei Feng Xiangming Wang Kang Shen
author_sort	Yinsuo Zhao
title	Metaxins are core components of mitochondrial transport adaptor complexes
title_short	Metaxins are core components of mitochondrial transport adaptor complexes
title_full	Metaxins are core components of mitochondrial transport adaptor complexes
title_fullStr	Metaxins are core components of mitochondrial transport adaptor complexes
title_full_unstemmed	Metaxins are core components of mitochondrial transport adaptor complexes
title_sort	metaxins are core components of mitochondrial transport adaptor complexes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0783f54a8c0745b8bb0ac55817195541
work_keys_str_mv	AT yinsuozhao metaxinsarecorecomponentsofmitochondrialtransportadaptorcomplexes AT elisong metaxinsarecorecomponentsofmitochondrialtransportadaptorcomplexes AT wenjuanwang metaxinsarecorecomponentsofmitochondrialtransportadaptorcomplexes AT chunghanhsieh metaxinsarecorecomponentsofmitochondrialtransportadaptorcomplexes AT xinnanwang metaxinsarecorecomponentsofmitochondrialtransportadaptorcomplexes AT weifeng metaxinsarecorecomponentsofmitochondrialtransportadaptorcomplexes AT xiangmingwang metaxinsarecorecomponentsofmitochondrialtransportadaptorcomplexes AT kangshen metaxinsarecorecomponentsofmitochondrialtransportadaptorcomplexes
_version_	1718388298514169856

Metaxins are core components of mitochondrial transport adaptor complexes

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