Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue and anatomical contexts of renal homeostasis.

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Auteurs principaux: Jacklyn N. Hellwege, Digna R. Velez Edwards, Ayush Giri, Chengxiang Qiu, Jihwan Park, Eric S. Torstenson, Jacob M. Keaton, O. D. Wilson, Cassianne Robinson-Cohen, Cecilia P. Chung, Christianne L. Roumie, Derek Klarin, Scott M. Damrauer, Scott L. DuVall, Edward Siew, Elvis A. Akwo, Matthias Wuttke, Mathias Gorski, Man Li, Yong Li, J. Michael Gaziano, Peter W. F. Wilson, Philip S. Tsao, Christopher J. O’Donnell, Csaba P. Kovesdy, Cristian Pattaro, Anna Köttgen, Katalin Susztak, Todd L. Edwards, Adriana M. Hung
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Science
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Accès en ligne:https://doaj.org/article/079924eecab64f9385dcb0971012c077
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https://doaj.org/article/079924eecab64f9385dcb0971012c077

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