Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program
Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue and anatomical contexts of renal homeostasis.
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Nature Portfolio
2019
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oai:doaj.org-article:079924eecab64f9385dcb0971012c0772021-12-02T15:35:29ZMapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program10.1038/s41467-019-11704-w2041-1723https://doaj.org/article/079924eecab64f9385dcb0971012c0772019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11704-whttps://doaj.org/toc/2041-1723Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue and anatomical contexts of renal homeostasis.Jacklyn N. HellwegeDigna R. Velez EdwardsAyush GiriChengxiang QiuJihwan ParkEric S. TorstensonJacob M. KeatonO. D. WilsonCassianne Robinson-CohenCecilia P. ChungChristianne L. RoumieDerek KlarinScott M. DamrauerScott L. DuVallEdward SiewElvis A. AkwoMatthias WuttkeMathias GorskiMan LiYong LiJ. Michael GazianoPeter W. F. WilsonPhilip S. TsaoChristopher J. O’DonnellCsaba P. KovesdyCristian PattaroAnna KöttgenKatalin SusztakTodd L. EdwardsAdriana M. HungNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
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DOAJ |
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Science Q |
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Science Q Jacklyn N. Hellwege Digna R. Velez Edwards Ayush Giri Chengxiang Qiu Jihwan Park Eric S. Torstenson Jacob M. Keaton O. D. Wilson Cassianne Robinson-Cohen Cecilia P. Chung Christianne L. Roumie Derek Klarin Scott M. Damrauer Scott L. DuVall Edward Siew Elvis A. Akwo Matthias Wuttke Mathias Gorski Man Li Yong Li J. Michael Gaziano Peter W. F. Wilson Philip S. Tsao Christopher J. O’Donnell Csaba P. Kovesdy Cristian Pattaro Anna Köttgen Katalin Susztak Todd L. Edwards Adriana M. Hung Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program |
| description |
Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue and anatomical contexts of renal homeostasis. |
| format |
article |
| author |
Jacklyn N. Hellwege Digna R. Velez Edwards Ayush Giri Chengxiang Qiu Jihwan Park Eric S. Torstenson Jacob M. Keaton O. D. Wilson Cassianne Robinson-Cohen Cecilia P. Chung Christianne L. Roumie Derek Klarin Scott M. Damrauer Scott L. DuVall Edward Siew Elvis A. Akwo Matthias Wuttke Mathias Gorski Man Li Yong Li J. Michael Gaziano Peter W. F. Wilson Philip S. Tsao Christopher J. O’Donnell Csaba P. Kovesdy Cristian Pattaro Anna Köttgen Katalin Susztak Todd L. Edwards Adriana M. Hung |
| author_facet |
Jacklyn N. Hellwege Digna R. Velez Edwards Ayush Giri Chengxiang Qiu Jihwan Park Eric S. Torstenson Jacob M. Keaton O. D. Wilson Cassianne Robinson-Cohen Cecilia P. Chung Christianne L. Roumie Derek Klarin Scott M. Damrauer Scott L. DuVall Edward Siew Elvis A. Akwo Matthias Wuttke Mathias Gorski Man Li Yong Li J. Michael Gaziano Peter W. F. Wilson Philip S. Tsao Christopher J. O’Donnell Csaba P. Kovesdy Cristian Pattaro Anna Köttgen Katalin Susztak Todd L. Edwards Adriana M. Hung |
| author_sort |
Jacklyn N. Hellwege |
| title |
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program |
| title_short |
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program |
| title_full |
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program |
| title_fullStr |
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program |
| title_full_unstemmed |
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program |
| title_sort |
mapping egfr loci to the renal transcriptome and phenome in the va million veteran program |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/079924eecab64f9385dcb0971012c077 |
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