Broad activation of latent HIV-1 in vivo

Treatment of HIV-1 infected patients with latency-reversing agents (LRA) induces transcription of proviruses in CD4 T cells. Using single-genome sequencing, the authors show that the LRA-induced CD4 T cell-associated HIV RNA is genetically diverse and contains a high proportion of defective RNA.

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Autores principales:	Kirston Barton, Bonnie Hiener, Anni Winckelmann, Thomas Aagaard Rasmussen, Wei Shao, Karen Byth, Robert Lanfear, Ajantha Solomon, James McMahon, Sean Harrington, Maria Buzon, Mathias Lichterfeld, Paul W. Denton, Rikke Olesen, Lars Østergaard, Martin Tolstrup, Sharon R. Lewin, Ole Schmeltz Søgaard, Sarah Palmer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07b5827ef392461e8e435aa6680c0e9b
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spelling	oai:doaj.org-article:07b5827ef392461e8e435aa6680c0e9b2021-12-02T17:31:33ZBroad activation of latent HIV-1 in vivo10.1038/ncomms127312041-1723https://doaj.org/article/07b5827ef392461e8e435aa6680c0e9b2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12731https://doaj.org/toc/2041-1723Treatment of HIV-1 infected patients with latency-reversing agents (LRA) induces transcription of proviruses in CD4 T cells. Using single-genome sequencing, the authors show that the LRA-induced CD4 T cell-associated HIV RNA is genetically diverse and contains a high proportion of defective RNA.Kirston BartonBonnie HienerAnni WinckelmannThomas Aagaard RasmussenWei ShaoKaren BythRobert LanfearAjantha SolomonJames McMahonSean HarringtonMaria BuzonMathias LichterfeldPaul W. DentonRikke OlesenLars ØstergaardMartin TolstrupSharon R. LewinOle Schmeltz SøgaardSarah PalmerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kirston Barton Bonnie Hiener Anni Winckelmann Thomas Aagaard Rasmussen Wei Shao Karen Byth Robert Lanfear Ajantha Solomon James McMahon Sean Harrington Maria Buzon Mathias Lichterfeld Paul W. Denton Rikke Olesen Lars Østergaard Martin Tolstrup Sharon R. Lewin Ole Schmeltz Søgaard Sarah Palmer Broad activation of latent HIV-1 in vivo
description	Treatment of HIV-1 infected patients with latency-reversing agents (LRA) induces transcription of proviruses in CD4 T cells. Using single-genome sequencing, the authors show that the LRA-induced CD4 T cell-associated HIV RNA is genetically diverse and contains a high proportion of defective RNA.
format	article
author	Kirston Barton Bonnie Hiener Anni Winckelmann Thomas Aagaard Rasmussen Wei Shao Karen Byth Robert Lanfear Ajantha Solomon James McMahon Sean Harrington Maria Buzon Mathias Lichterfeld Paul W. Denton Rikke Olesen Lars Østergaard Martin Tolstrup Sharon R. Lewin Ole Schmeltz Søgaard Sarah Palmer
author_facet	Kirston Barton Bonnie Hiener Anni Winckelmann Thomas Aagaard Rasmussen Wei Shao Karen Byth Robert Lanfear Ajantha Solomon James McMahon Sean Harrington Maria Buzon Mathias Lichterfeld Paul W. Denton Rikke Olesen Lars Østergaard Martin Tolstrup Sharon R. Lewin Ole Schmeltz Søgaard Sarah Palmer
author_sort	Kirston Barton
title	Broad activation of latent HIV-1 in vivo
title_short	Broad activation of latent HIV-1 in vivo
title_full	Broad activation of latent HIV-1 in vivo
title_fullStr	Broad activation of latent HIV-1 in vivo
title_full_unstemmed	Broad activation of latent HIV-1 in vivo
title_sort	broad activation of latent hiv-1 in vivo
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/07b5827ef392461e8e435aa6680c0e9b
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Broad activation of latent HIV-1 in vivo

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