Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma

Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma

Immunotherapy has demonstrated significant activity in a broad range of cancer types, but still the majority of patients receiving it do not maintain durable therapeutic responses. Amino acid metabolism has been proposed to be involved in the regulation of immune response. Here, we investigated in d...

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Autores principales: Anna Sosnowska, Justyna Chlebowska-Tuz, Pawel Matryba, Zofia Pilch, Alan Greig, Artur Wolny, Tomasz M. Grzywa, Zuzanna Rydzynska, Olga Sokolowska, Tomasz P. Rygiel, Marcin Grzybowski, Paulina Stanczak, Roman Blaszczyk, Dominika Nowis, Jakub Golab
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2021
Materias:
arginase
tumor microenvironment
immunosuppression
arginase inhibitor
immunotherapy
t-cells response
myeloid cells
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/07d158283324431ba6734d685c57a6a0
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https://doaj.org/article/07d158283324431ba6734d685c57a6a0

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