High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM

Despite many recent advances in cryo-EM, imaging smaller macromolecules (below 100 kDa) has remained a challenge. Here the authors show that biological specimens amassing <100 kDa can be resolved to better than 3 Å resolution using conventional defocus-based single-particle analysis methods....

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Autores principales: Mark A. Herzik, Mengyu Wu, Gabriel C. Lander
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/082a304c2b0a4f3b94de0ccbd7867848
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