High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM
Despite many recent advances in cryo-EM, imaging smaller macromolecules (below 100 kDa) has remained a challenge. Here the authors show that biological specimens amassing <100 kDa can be resolved to better than 3 Å resolution using conventional defocus-based single-particle analysis methods....
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Autores principales: | Mark A. Herzik, Mengyu Wu, Gabriel C. Lander |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/082a304c2b0a4f3b94de0ccbd7867848 |
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