Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines

A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal...

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Autores principales:	William M. de Souza, Stéfanie P. Muraro, Gabriela F. Souza, Mariene R. Amorim, Renata Sesti-Costa, Luciana S. Mofatto, Julia Forato, Priscilla P. Barbosa, Daniel A. Toledo-Teixeira, Karina Bispo-dos-Santos, Pierina L. Parise, Natalia S. Brunetti, Joselia C. O. Moreira, Vitor A. Costa, Daniela M. Cardozo, Maria L. Moretti, Silvia Barros-Mazon, Gabriela F. Marchesi, Christiane Ambrosio, Fernando R. Spilki, Valeria C. Almeida, Andre S. Vieira, Lair Zambon, Alessandro S. Farias, Marcelo Addas-Carvalho, Bruno D. Benites, Rafael E. Marques, Ester C. Sabino, Andrea B. Von Zuben, Scott C. Weaver, Nuno R. Faria, Fabiana Granja, Rodrigo N. Angerami, José Luiz Proença-Módena
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 variant of concern B.1.1.7 vaccine outbreak Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/084c74eea275456eb320f5f7c03ed4f6
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spelling	oai:doaj.org-article:084c74eea275456eb320f5f7c03ed4f62021-11-25T19:12:30ZClusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines10.3390/v131121271999-4915https://doaj.org/article/084c74eea275456eb320f5f7c03ed4f62021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2127https://doaj.org/toc/1999-4915A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with a single-dose of ChAdOx1 (outbreak A, <i>n</i> = 26), and 22 of 42 of individuals with two doses of the CoronaVac vaccine (outbreak B, <i>n</i> = 52) for breakthrough infection rates for ChAdOx1 of 63.6% and 52.4% for CoronaVac. The outbreaks were caused by two independent clusters of the B.1.1.7 VOC. The serum of PCR-positive symptomatic SARS-CoV-2-infected individuals had ~1.8–3.4-fold more neutralizing capacity against B.1.1.7 compared to the serum of asymptomatic individuals. These data based on exploratory analysis suggest that the B.1.1.7 variant can infect individuals partially immunized with a single dose of an adenovirus-vectored vaccine or fully immunized with two doses of an inactivated vaccine, although the vaccines were able to reduce the risk of severe disease and death caused by this VOC, even in the elderly.William M. de SouzaStéfanie P. MuraroGabriela F. SouzaMariene R. AmorimRenata Sesti-CostaLuciana S. MofattoJulia ForatoPriscilla P. BarbosaDaniel A. Toledo-TeixeiraKarina Bispo-dos-SantosPierina L. PariseNatalia S. BrunettiJoselia C. O. MoreiraVitor A. CostaDaniela M. CardozoMaria L. MorettiSilvia Barros-MazonGabriela F. MarchesiChristiane AmbrosioFernando R. SpilkiValeria C. AlmeidaAndre S. VieiraLair ZambonAlessandro S. FariasMarcelo Addas-CarvalhoBruno D. BenitesRafael E. MarquesEster C. SabinoAndrea B. Von ZubenScott C. WeaverNuno R. FariaFabiana GranjaRodrigo N. AngeramiJosé Luiz Proença-MódenaMDPI AGarticleSARS-CoV-2COVID-19variant of concernB.1.1.7vaccineoutbreakMicrobiologyQR1-502ENViruses, Vol 13, Iss 2127, p 2127 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 variant of concern B.1.1.7 vaccine outbreak Microbiology QR1-502
spellingShingle	SARS-CoV-2 COVID-19 variant of concern B.1.1.7 vaccine outbreak Microbiology QR1-502 William M. de Souza Stéfanie P. Muraro Gabriela F. Souza Mariene R. Amorim Renata Sesti-Costa Luciana S. Mofatto Julia Forato Priscilla P. Barbosa Daniel A. Toledo-Teixeira Karina Bispo-dos-Santos Pierina L. Parise Natalia S. Brunetti Joselia C. O. Moreira Vitor A. Costa Daniela M. Cardozo Maria L. Moretti Silvia Barros-Mazon Gabriela F. Marchesi Christiane Ambrosio Fernando R. Spilki Valeria C. Almeida Andre S. Vieira Lair Zambon Alessandro S. Farias Marcelo Addas-Carvalho Bruno D. Benites Rafael E. Marques Ester C. Sabino Andrea B. Von Zuben Scott C. Weaver Nuno R. Faria Fabiana Granja Rodrigo N. Angerami José Luiz Proença-Módena Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
description	A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with a single-dose of ChAdOx1 (outbreak A, <i>n</i> = 26), and 22 of 42 of individuals with two doses of the CoronaVac vaccine (outbreak B, <i>n</i> = 52) for breakthrough infection rates for ChAdOx1 of 63.6% and 52.4% for CoronaVac. The outbreaks were caused by two independent clusters of the B.1.1.7 VOC. The serum of PCR-positive symptomatic SARS-CoV-2-infected individuals had ~1.8–3.4-fold more neutralizing capacity against B.1.1.7 compared to the serum of asymptomatic individuals. These data based on exploratory analysis suggest that the B.1.1.7 variant can infect individuals partially immunized with a single dose of an adenovirus-vectored vaccine or fully immunized with two doses of an inactivated vaccine, although the vaccines were able to reduce the risk of severe disease and death caused by this VOC, even in the elderly.
format	article
author	William M. de Souza Stéfanie P. Muraro Gabriela F. Souza Mariene R. Amorim Renata Sesti-Costa Luciana S. Mofatto Julia Forato Priscilla P. Barbosa Daniel A. Toledo-Teixeira Karina Bispo-dos-Santos Pierina L. Parise Natalia S. Brunetti Joselia C. O. Moreira Vitor A. Costa Daniela M. Cardozo Maria L. Moretti Silvia Barros-Mazon Gabriela F. Marchesi Christiane Ambrosio Fernando R. Spilki Valeria C. Almeida Andre S. Vieira Lair Zambon Alessandro S. Farias Marcelo Addas-Carvalho Bruno D. Benites Rafael E. Marques Ester C. Sabino Andrea B. Von Zuben Scott C. Weaver Nuno R. Faria Fabiana Granja Rodrigo N. Angerami José Luiz Proença-Módena
author_facet	William M. de Souza Stéfanie P. Muraro Gabriela F. Souza Mariene R. Amorim Renata Sesti-Costa Luciana S. Mofatto Julia Forato Priscilla P. Barbosa Daniel A. Toledo-Teixeira Karina Bispo-dos-Santos Pierina L. Parise Natalia S. Brunetti Joselia C. O. Moreira Vitor A. Costa Daniela M. Cardozo Maria L. Moretti Silvia Barros-Mazon Gabriela F. Marchesi Christiane Ambrosio Fernando R. Spilki Valeria C. Almeida Andre S. Vieira Lair Zambon Alessandro S. Farias Marcelo Addas-Carvalho Bruno D. Benites Rafael E. Marques Ester C. Sabino Andrea B. Von Zuben Scott C. Weaver Nuno R. Faria Fabiana Granja Rodrigo N. Angerami José Luiz Proença-Módena
author_sort	William M. de Souza
title	Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
title_short	Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
title_full	Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
title_fullStr	Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
title_full_unstemmed	Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
title_sort	clusters of sars-cov-2 lineage b.1.1.7 infection after vaccination with adenovirus-vectored and inactivated vaccines
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/084c74eea275456eb320f5f7c03ed4f6
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Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines

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