The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

Abstract Membrane ruffling and lamellipodia formation promote the motility of adherent cells in two-dimensional motility assays by mechano-sensing of the microenvironment and initiation of focal adhesions towards their surroundings. Lamellipodium formation is stimulated by small Rho GTPases of the R...

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Autores principales: Tom Kunschmann, Stefanie Puder, Tony Fischer, Anika Steffen, Klemens Rottner, Claudia Tanja Mierke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/089cc43f77f24eed88bb58c431e6860b
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