The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices
Abstract Membrane ruffling and lamellipodia formation promote the motility of adherent cells in two-dimensional motility assays by mechano-sensing of the microenvironment and initiation of focal adhesions towards their surroundings. Lamellipodium formation is stimulated by small Rho GTPases of the R...
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Autores principales: | Tom Kunschmann, Stefanie Puder, Tony Fischer, Anika Steffen, Klemens Rottner, Claudia Tanja Mierke |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Acceso en línea: | https://doaj.org/article/089cc43f77f24eed88bb58c431e6860b |
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