MYCN amplification and ATRX mutations are incompatible in neuroblastoma
In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.
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Nature Portfolio
2020
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oai:doaj.org-article:08a87c1bf95d4f798e9e0d5a7daabd612021-12-02T16:56:32ZMYCN amplification and ATRX mutations are incompatible in neuroblastoma10.1038/s41467-020-14682-62041-1723https://doaj.org/article/08a87c1bf95d4f798e9e0d5a7daabd612020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14682-6https://doaj.org/toc/2041-1723In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.Maged ZeineldinSara FedericoXiang ChenYiping FanBeisi XuElizabeth StewartXin ZhouJongrye JeonLyra GriffithsRosa NguyenJackie NorrieJohn EastonHeather MulderDonald YergeauYanling LiuJianrong WuCollin Van RynArlene NaranjoMichael D. HogartyMarcin M. KamińskiMarc ValentineShondra M. Pruett-MillerAlberto PappoJinghui ZhangMichael R. ClayArmita BahramiPeter VogelSeungjae LeeAnang ShelatJay F. SarthyMichael P. MeersRani E. GeorgeElaine R. MardisRichard K. WilsonSteven HenikoffJames R. DowningMichael A. DyerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Maged Zeineldin Sara Federico Xiang Chen Yiping Fan Beisi Xu Elizabeth Stewart Xin Zhou Jongrye Jeon Lyra Griffiths Rosa Nguyen Jackie Norrie John Easton Heather Mulder Donald Yergeau Yanling Liu Jianrong Wu Collin Van Ryn Arlene Naranjo Michael D. Hogarty Marcin M. Kamiński Marc Valentine Shondra M. Pruett-Miller Alberto Pappo Jinghui Zhang Michael R. Clay Armita Bahrami Peter Vogel Seungjae Lee Anang Shelat Jay F. Sarthy Michael P. Meers Rani E. George Elaine R. Mardis Richard K. Wilson Steven Henikoff James R. Downing Michael A. Dyer MYCN amplification and ATRX mutations are incompatible in neuroblastoma |
| description |
In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible. |
| format |
article |
| author |
Maged Zeineldin Sara Federico Xiang Chen Yiping Fan Beisi Xu Elizabeth Stewart Xin Zhou Jongrye Jeon Lyra Griffiths Rosa Nguyen Jackie Norrie John Easton Heather Mulder Donald Yergeau Yanling Liu Jianrong Wu Collin Van Ryn Arlene Naranjo Michael D. Hogarty Marcin M. Kamiński Marc Valentine Shondra M. Pruett-Miller Alberto Pappo Jinghui Zhang Michael R. Clay Armita Bahrami Peter Vogel Seungjae Lee Anang Shelat Jay F. Sarthy Michael P. Meers Rani E. George Elaine R. Mardis Richard K. Wilson Steven Henikoff James R. Downing Michael A. Dyer |
| author_facet |
Maged Zeineldin Sara Federico Xiang Chen Yiping Fan Beisi Xu Elizabeth Stewart Xin Zhou Jongrye Jeon Lyra Griffiths Rosa Nguyen Jackie Norrie John Easton Heather Mulder Donald Yergeau Yanling Liu Jianrong Wu Collin Van Ryn Arlene Naranjo Michael D. Hogarty Marcin M. Kamiński Marc Valentine Shondra M. Pruett-Miller Alberto Pappo Jinghui Zhang Michael R. Clay Armita Bahrami Peter Vogel Seungjae Lee Anang Shelat Jay F. Sarthy Michael P. Meers Rani E. George Elaine R. Mardis Richard K. Wilson Steven Henikoff James R. Downing Michael A. Dyer |
| author_sort |
Maged Zeineldin |
| title |
MYCN amplification and ATRX mutations are incompatible in neuroblastoma |
| title_short |
MYCN amplification and ATRX mutations are incompatible in neuroblastoma |
| title_full |
MYCN amplification and ATRX mutations are incompatible in neuroblastoma |
| title_fullStr |
MYCN amplification and ATRX mutations are incompatible in neuroblastoma |
| title_full_unstemmed |
MYCN amplification and ATRX mutations are incompatible in neuroblastoma |
| title_sort |
mycn amplification and atrx mutations are incompatible in neuroblastoma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/08a87c1bf95d4f798e9e0d5a7daabd61 |
| work_keys_str_mv |
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