Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing

Adaptive immunity from both B and T cells critically controls the rejection or survival of transplanted organs. Here the authors show, by analyzing human B cell receptor repertoire in longitudinal studies of patients receiving kidney transplants, that repertoire diversity is positively associated wi...

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Autores principales: Silvia Pineda, Tara K. Sigdel, Juliane M. Liberto, Flavio Vincenti, Marina Sirota, Minnie M. Sarwal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/08b11559921a47c3bbc1810bb121763c
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Sumario:Adaptive immunity from both B and T cells critically controls the rejection or survival of transplanted organs. Here the authors show, by analyzing human B cell receptor repertoire in longitudinal studies of patients receiving kidney transplants, that repertoire diversity is positively associated with the incidence of kidney rejection.