A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.

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Detalles Bibliográficos
Autores principales:	Nicoletta I. Petridou, Paris A. Skourides
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08c31188016642ab98f554081dcd7e8b
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id	oai:doaj.org-article:08c31188016642ab98f554081dcd7e8b
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spelling	oai:doaj.org-article:08c31188016642ab98f554081dcd7e8b2021-12-02T14:39:49ZA ligand-independent integrin β1 mechanosensory complex guides spindle orientation10.1038/ncomms108992041-1723https://doaj.org/article/08c31188016642ab98f554081dcd7e8b2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10899https://doaj.org/toc/2041-1723During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.Nicoletta I. PetridouParis A. SkouridesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicoletta I. Petridou Paris A. Skourides A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
description	During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.
format	article
author	Nicoletta I. Petridou Paris A. Skourides
author_facet	Nicoletta I. Petridou Paris A. Skourides
author_sort	Nicoletta I. Petridou
title	A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_short	A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_full	A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_fullStr	A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_full_unstemmed	A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_sort	ligand-independent integrin β1 mechanosensory complex guides spindle orientation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/08c31188016642ab98f554081dcd7e8b
work_keys_str_mv	AT nicolettaipetridou aligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT parisaskourides aligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT nicolettaipetridou ligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT parisaskourides ligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation
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A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

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