A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.
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Nature Portfolio
2016
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oai:doaj.org-article:08c31188016642ab98f554081dcd7e8b2021-12-02T14:39:49ZA ligand-independent integrin β1 mechanosensory complex guides spindle orientation10.1038/ncomms108992041-1723https://doaj.org/article/08c31188016642ab98f554081dcd7e8b2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10899https://doaj.org/toc/2041-1723During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.Nicoletta I. PetridouParis A. SkouridesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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Science Q Nicoletta I. Petridou Paris A. Skourides A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
description |
During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding. |
format |
article |
author |
Nicoletta I. Petridou Paris A. Skourides |
author_facet |
Nicoletta I. Petridou Paris A. Skourides |
author_sort |
Nicoletta I. Petridou |
title |
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
title_short |
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
title_full |
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
title_fullStr |
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
title_full_unstemmed |
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
title_sort |
ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/08c31188016642ab98f554081dcd7e8b |
work_keys_str_mv |
AT nicolettaipetridou aligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT parisaskourides aligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT nicolettaipetridou ligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT parisaskourides ligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation |
_version_ |
1718390457429393408 |