A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.

Guardado en:
Detalles Bibliográficos
Autores principales: Nicoletta I. Petridou, Paris A. Skourides
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Q
Acceso en línea:https://doaj.org/article/08c31188016642ab98f554081dcd7e8b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:08c31188016642ab98f554081dcd7e8b
record_format dspace
spelling oai:doaj.org-article:08c31188016642ab98f554081dcd7e8b2021-12-02T14:39:49ZA ligand-independent integrin β1 mechanosensory complex guides spindle orientation10.1038/ncomms108992041-1723https://doaj.org/article/08c31188016642ab98f554081dcd7e8b2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10899https://doaj.org/toc/2041-1723During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.Nicoletta I. PetridouParis A. SkouridesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nicoletta I. Petridou
Paris A. Skourides
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
description During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.
format article
author Nicoletta I. Petridou
Paris A. Skourides
author_facet Nicoletta I. Petridou
Paris A. Skourides
author_sort Nicoletta I. Petridou
title A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_short A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_full A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_fullStr A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_full_unstemmed A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
title_sort ligand-independent integrin β1 mechanosensory complex guides spindle orientation
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/08c31188016642ab98f554081dcd7e8b
work_keys_str_mv AT nicolettaipetridou aligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation
AT parisaskourides aligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation
AT nicolettaipetridou ligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation
AT parisaskourides ligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation
_version_ 1718390457429393408