Smoking shifts human small airway epithelium club cells toward a lesser differentiated population

Abstract The club cell, a small airway epithelial (SAE) cell, plays a central role in human lung host defense. We hypothesized that subpopulations of club cells with distinct functions may exist. The SAE of healthy nonsmokers and healthy cigarette smokers were evaluated by single-cell RNA sequencing...

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Autores principales: Mahboubeh R. Rostami, Michelle G. LeBlanc, Yael Strulovici-Barel, Wulin Zuo, Jason G. Mezey, Sarah L. O’Beirne, Robert J. Kaner, Philip L. Leopold, Ronald G. Crystal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/08d73db7b3394c4286f74267ce717330
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