Smoking shifts human small airway epithelium club cells toward a lesser differentiated population

Abstract The club cell, a small airway epithelial (SAE) cell, plays a central role in human lung host defense. We hypothesized that subpopulations of club cells with distinct functions may exist. The SAE of healthy nonsmokers and healthy cigarette smokers were evaluated by single-cell RNA sequencing...

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Auteurs principaux: Mahboubeh R. Rostami, Michelle G. LeBlanc, Yael Strulovici-Barel, Wulin Zuo, Jason G. Mezey, Sarah L. O’Beirne, Robert J. Kaner, Philip L. Leopold, Ronald G. Crystal
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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R
Accès en ligne:https://doaj.org/article/08d73db7b3394c4286f74267ce717330
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