Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice.

Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice.

<h4>Background</h4>Macrophages, key regulators of healing/regeneration processes, strongly infiltrate ischemic tissues from patients suffering from critical limb ischemia (CLI). However pro-inflammatory markers correlate with disease progression and risk of amputation, suggesting that mo...

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Autores principales: Nicolas Bréchot, Elisa Gomez, Marine Bignon, Jamila Khallou-Laschet, Michael Dussiot, Aurélie Cazes, Cécile Alanio-Bréchot, Mélanie Durand, Josette Philippe, Jean-Sébastien Silvestre, Nico Van Rooijen, Pierre Corvol, Antonino Nicoletti, Bénédicte Chazaud, Stéphane Germain
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/092bce29b2fc4413887a21351ab8dccd
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https://doaj.org/article/092bce29b2fc4413887a21351ab8dccd

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